Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing

• Main Authors: Hui-min, Neoh, Mee, Lee Looi, Muhiddin Ishak,, Mohd Ridhwan Abd Razak,, Noor Hamidah Hussin,, Zarina Latiff,, Hamidah Alias,, Rahman Jamal,
• Format: Article
• Language: English
• Published: Penerbit UKM 2012
• Online Access: http://journalarticle.ukm.my/6092/1/2011-1-17.pdf; http://journalarticle.ukm.my/6092/; http://www.ukm.my/apjmm/

This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT*2), G460A (TPMT*3B) and A719G (TPMT*3C) loci was determined in 89 subjects...