Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain

The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also hi...

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Bibliographic Details
Main Authors: Danial Yahya, M., Chien , C. Lung, Yacob L. Pinnas,
Format: Article
Published: Universiti Kebangsaan Malaysia 1996
Online Access:http://journalarticle.ukm.my/3681/
http://www.ukm.my/jsm/english_journals/vol25num1_1996/vol25num1_96page77-86.html
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Summary:The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice.