RAD50 deficiency and its effects on zebrafish embryonic development and DNA repair mechanisms

• المؤلفون الرئيسيون: Nahid Khalili,, Shazrul Fazry,, Mahmood, Ibrahim, Ahmed Najm,, Ahmad Azfaralariff,
• التنسيق: مقال
• اللغة: English
• منشور في: Penerbit Universiti Kebangsaan Malaysia 2024
• الوصول للمادة أونلاين: http://journalarticle.ukm.my/24752/1/MAE%204.pdf; http://journalarticle.ukm.my/24752/; https://jms.mabjournal.com/index.php/mab/issue/view/63

The MRE11-RAD50-NBS1 (MRN) complex is essential in detecting, signaling, and repairing DNA double-strand breaks (DSBs), thus maintaining genomic integrity. Mutations in RAD50 are linked to severe conditions such as microcephaly, mental retardation, and growth retardation in humans. This study invest...