Synthesis and characterization of hexahydropyrimidines and their new derivatives

• Main Authors: Hamed, Shukkur A., Thaker, Athraa, Rudaini, Bilal Majid, Naeem, Hasanain Salah, Muntaz Abu Bakar,, Siti Aishah Hasbullah,
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Online Access: http://journalarticle.ukm.my/23917/1/SE%209.pdf; http://journalarticle.ukm.my/23917/; https://www.ukm.my/jsm/english_journals/vol53num4_2024/contentsVol53num4_2024.html

Three new hexahydropyrimidine derivatives 1a – 1c were successfully synthesized using the Mannich-type reaction. Furthermore, the synthesis of three amino bases 2a – 2c was achieved through the reduction reaction of pyrimidine compounds using hydrazine, followed by the substitution reaction of nitro...