In Vitro and In Silico study on the interaction between apigenin, kaempferoland 4-hydroxybenzoic acid in xanthine oxidase inhibition

• Main Authors: Chin, Yong Sin, Loh, Khye Er, Wee, Sze Ping, Ong, Ghim Hock
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2023
• Online Access: http://journalarticle.ukm.my/22783/1/SEN%203.pdf; http://journalarticle.ukm.my/22783/; https://www.ukm.my/jsm/english_journals/vol52num6_2023/contentsVol52num6_2023.html

Xanthine oxidase (XO) is a biological enzyme that takes part in purine catabolism. It catalyses the conversion of hypoxanthine to xanthine and eventually xanthine to uric acid. The catabolism reaction increases the level of uric acid and subsequently leads to hyperuricemia. Allopurinol is a XO inhib...