Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report

Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasou...

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Main Authors: Siti-Aishah M.A.,, Salwati S,,, Idrus M.,, Rahimah R.,, Salmi A.,, Leong C.F.,, Sharifah N.A,
Format: Article
Language:English
Published: Penerbit UKM 2008
Online Access:http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf
http://journalarticle.ukm.my/2021/
http://www.ppukm.ukm.my/ukmmcjournal/index.php
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spelling my-ukm.journal.20212016-12-14T06:30:41Z http://journalarticle.ukm.my/2021/ Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological examination revealed that the mass was infiltrated by large lymphoid cells with marked nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation. Subsequently the patient developed shortness of the breath and a thoracic computed tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The mediastinum and endobronchial region did not show any abnormalities. She received 6 cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL, rarely present as a soft tissue tumour and this disease should be included as a differential diagnosis of any soft tissue mass Penerbit UKM 2008 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf Siti-Aishah M.A., and Salwati S,, and Idrus M., and Rahimah R., and Salmi A., and Leong C.F., and Sharifah N.A, (2008) Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report. Medicine & Health, 3 (1). pp. 69-74. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological examination revealed that the mass was infiltrated by large lymphoid cells with marked nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation. Subsequently the patient developed shortness of the breath and a thoracic computed tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The mediastinum and endobronchial region did not show any abnormalities. She received 6 cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL, rarely present as a soft tissue tumour and this disease should be included as a differential diagnosis of any soft tissue mass
format Article
author Siti-Aishah M.A.,
Salwati S,,
Idrus M.,
Rahimah R.,
Salmi A.,
Leong C.F.,
Sharifah N.A,
spellingShingle Siti-Aishah M.A.,
Salwati S,,
Idrus M.,
Rahimah R.,
Salmi A.,
Leong C.F.,
Sharifah N.A,
Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
author_facet Siti-Aishah M.A.,
Salwati S,,
Idrus M.,
Rahimah R.,
Salmi A.,
Leong C.F.,
Sharifah N.A,
author_sort Siti-Aishah M.A.,
title Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_short Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_full Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_fullStr Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_full_unstemmed Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_sort anaplastic large cell lymphoma presenting as a soft tissue mass – a case report
publisher Penerbit UKM
publishDate 2008
url http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf
http://journalarticle.ukm.my/2021/
http://www.ppukm.ukm.my/ukmmcjournal/index.php
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