Fluoxetine affects intestinal motility via 5-HT3 and muscarinic receptors in ex vivo mouse model

• Main Authors: Pissared Khuituan,, Chotika Nhaemchei,, Sakda Pradab,, Sakena K-da,, Nipaporn Konthapakdee,
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2021
• Online Access: http://journalarticle.ukm.my/18332/1/15.pdf; http://journalarticle.ukm.my/18332/; https://www.ukm.my/jsm/malay_journals/jilid50bil12_2021/KandunganJilid50Bil12_2021.html

Fluoxetine, a selective serotonin reuptake inhibitor anti-depressant, causes undesirable side effects, including diarrhea and constipation. This research investigated the direct effects of fluoxetine at 0.001, 0.01, 0.1, 1, 10, and 100 μM on duodenal and proximal colonic tissue contractions. The inv...