Detection of BCR/ABL gene in chronic Myeloid Leukaemia: comparison of Fluorescence in situ Hybridisation (FISH), conventional Cytogenetics and Polymerase Chain Reaction (PCR) techniques

• Main Authors: Reena RMZ,, Julia Munchar MJ,, Salwati S,,, Hamidah NH,, Zubaidah Z,, Sharifah NA,, Cheong SK,
• Format: Article
• Language: English
• Published: Penerbit UKM 2006
• Online Access: http://journalarticle.ukm.my/1829/1/02._5-13_%28MH_006%29.pdf; http://journalarticle.ukm.my/1829/; http://www.ppukm.ukm.my/ukmmcjournal/index.php

The reciprocal translocation t(9;22)(q34;q11) which gives rise to the Philadelphia (Ph1) chromosome and BCR/ABL fusion gene, plays a pivotal role in the diagnosis and pathogenesis of chronic myeloid leukemia (CML). In this study, we evaluated the role of fluorescence in situ hybridisation (FISH) in...