Protective effect of Copaifera salikounda heckel against paracetamol-induced hepatorenal injury in rat
Drug-induced hepatorenal damage is a significant worldwide clinical challenge. In Nigeria, Copaifera salikounda seed pod ethanol extract (CSSPEE) is used in the treatment of many ailments including liver disorders. This study investigated the protective efficacy of CSSPEE against paracetamol (PC...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17179/1/17.pdf http://journalarticle.ukm.my/17179/ https://www.ukm.my/jsm/malay_journals/jilid50bil4_2021/KandunganJilid50Bil4_2021.html |
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| Summary: | Drug-induced hepatorenal damage is a significant worldwide clinical challenge. In Nigeria, Copaifera salikounda
seed pod ethanol extract (CSSPEE) is used in the treatment of many ailments including liver disorders. This study
investigated the protective efficacy of CSSPEE against paracetamol (PCM) induced hepatorenal toxicity. Male
albino Wistar rats were assigned at random into five different groups (n = 6). The normal control (Group I) was given
normal saline via oral administration while Group II was given 500 mg/kg body weight of PCM via intra-peritoneal
administration; Group III was administered 100 mgkg-1 of silymarin (reference drug) while Groups IV and V were
administered 200 and 400 mg kg-1 of CSSPEE, respectively, per os for seven days prior to administration of PCM. CSSPEE
pretreated groups protected PCM-induced hepatorenal damage as reflected by significant diminution (P < 0.05) in liver
enzymes activities and levels of malondialdehyde (MDA), total bilirubin (TB), triglycerides (TG) and urea in comparison
with group II. Also, CSSPEE pretreatment significantly increased (P < 0.05) the activities of catalase and GSH relative
to group II while no significant elevation (P > 0.05) in superoxide dismutase (SOD), glutathione peroxidase (GPx), and
high-density lipoprotein (HDL) was observed in comparison to PCM group. CSSPEE also reversed liver and kidney PCM
overdose caused histopathological alterations and ameliorated the tissue histology thereby corroborating the results of
biochemical findings. CSSPEE produced analogous effects comparable to those produced by silymarin (reference drug).
The results indicated that oral administration of CSSPEE conferred a dose-dependent protection against paracetamol-induced oxidative damage to liver and kidney |
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