Cholinesterase inhibition activity and molecular docking study of eugenol derivatives
The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten eugenol derivatives were synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by Ellman’s method. Most of the te...
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Penerbit Universiti Kebangsaan Malaysia
2021
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Online Access: | http://journalarticle.ukm.my/17176/1/14.pdf http://journalarticle.ukm.my/17176/ https://www.ukm.my/jsm/malay_journals/jilid50bil4_2021/KandunganJilid50Bil4_2021.html |
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my-ukm.journal.171762021-07-26T02:52:02Z http://journalarticle.ukm.my/17176/ Cholinesterase inhibition activity and molecular docking study of eugenol derivatives Khairunisa Mohd Zamli, Asnuzilawati Asari, Hanis Mohd Yusof, Nurul Huda Abdul Wahab, Kooi, Yeong Khaw Vikneswaran Murugaiyah, al-Rashida, Mariya Habsah Mohamad, Hasnah Osman, The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten eugenol derivatives were synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by Ellman’s method. Most of the tested derivatives showed higher inhibition on BChE than AChE, however, their overall inhibitory activity was weak. In contrast, three derivatives (compounds 3,6,9) showed higher and good AChE inhibitory activity of more than 50% inhibition at 10 µg/mL. Among them, compound 9 bearing a ethyl substituent at para position of the benzoyl ring showed the most potent AChE inhibition, with IC50 of 5.64 µg/mL. Ligand-protein docking simulation was also performed for the most active derived molecules (compounds 3,6,9). Penerbit Universiti Kebangsaan Malaysia 2021-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17176/1/14.pdf Khairunisa Mohd Zamli, and Asnuzilawati Asari, and Hanis Mohd Yusof, and Nurul Huda Abdul Wahab, and Kooi, Yeong Khaw and Vikneswaran Murugaiyah, and al-Rashida, Mariya and Habsah Mohamad, and Hasnah Osman, (2021) Cholinesterase inhibition activity and molecular docking study of eugenol derivatives. Sains Malaysiana, 50 (4). pp. 1037-1045. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil4_2021/KandunganJilid50Bil4_2021.html |
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The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten
eugenol derivatives were synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE)
and butyrylcholinesterase (BChE) by Ellman’s method. Most of the tested derivatives showed higher inhibition on BChE
than AChE, however, their overall inhibitory activity was weak. In contrast, three derivatives (compounds 3,6,9) showed
higher and good AChE inhibitory activity of more than 50% inhibition at 10 µg/mL. Among them, compound 9
bearing a ethyl substituent at para position of the benzoyl ring showed the most potent AChE inhibition, with IC50 of 5.64
µg/mL. Ligand-protein docking simulation was also performed for the most active derived molecules (compounds 3,6,9). |
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Article |
author |
Khairunisa Mohd Zamli, Asnuzilawati Asari, Hanis Mohd Yusof, Nurul Huda Abdul Wahab, Kooi, Yeong Khaw Vikneswaran Murugaiyah, al-Rashida, Mariya Habsah Mohamad, Hasnah Osman, |
spellingShingle |
Khairunisa Mohd Zamli, Asnuzilawati Asari, Hanis Mohd Yusof, Nurul Huda Abdul Wahab, Kooi, Yeong Khaw Vikneswaran Murugaiyah, al-Rashida, Mariya Habsah Mohamad, Hasnah Osman, Cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
author_facet |
Khairunisa Mohd Zamli, Asnuzilawati Asari, Hanis Mohd Yusof, Nurul Huda Abdul Wahab, Kooi, Yeong Khaw Vikneswaran Murugaiyah, al-Rashida, Mariya Habsah Mohamad, Hasnah Osman, |
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Khairunisa Mohd Zamli, |
title |
Cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
title_short |
Cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
title_full |
Cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
title_fullStr |
Cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
title_full_unstemmed |
Cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
title_sort |
cholinesterase inhibition activity and molecular docking study of eugenol derivatives |
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Penerbit Universiti Kebangsaan Malaysia |
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2021 |
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http://journalarticle.ukm.my/17176/1/14.pdf http://journalarticle.ukm.my/17176/ https://www.ukm.my/jsm/malay_journals/jilid50bil4_2021/KandunganJilid50Bil4_2021.html |
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1706958274859892736 |
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13.160551 |