Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans
The diabetes mellitus is one of the chronic diseases that has high prevalence rates in the world. It is defined as a state of hyperglycemia which usually accompanied by increasing blood glucose level. The combination of Phyllanthus niruri herbs and Zingiber americans rhizome has been produced as her...
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Penerbit Universiti Kebangsaan Malaysia
2020
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my-ukm.journal.159122020-12-06T09:21:45Z http://journalarticle.ukm.my/15912/ Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans Elfahmi, Adnyana, I Ketut Fitria, Ika Taufikurahman, Taufik The diabetes mellitus is one of the chronic diseases that has high prevalence rates in the world. It is defined as a state of hyperglycemia which usually accompanied by increasing blood glucose level. The combination of Phyllanthus niruri herbs and Zingiber americans rhizome has been produced as herbal medicine for the treatment of diabetes. The efficacy of combination of these plants is still based on empirical data. This research aimed to prove the antidiabetes activity of herbal medicine product containing P. niruri and Z. americans in vivo. Antidiabetes activity was tested using oral glucose tolerance and alloxan induced methods. The blood glucose levels were measured in each experiment. In addition, the plasma triglyceride and total cholesterol levels were also measured. The results showed that the decrease of blood glucose levels on oral glucose tolerance method were 40.98, 44.84, and 47.02% at doses of 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. While the decrease in blood glucose levels in alloxan induced method were 33.05, 38.82, and 41.79% at dose 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. The extract of dose 203 mg/kg BW appeared to be the most potent to decrease blood glucose levels in both methods, but did not show suppression activity of triglycerides and total cholesterol plasma. Suppression activities of serum triglycerides and total cholesterol were shown after treatment with the extract dose 90 and 135 mg/kg BW, which were significantly different to control (p < 0.05). The herbal product contains flavonoid, phenol and tannin, which total of each were 0.15, 0.16, and 1.85% w/w, respectively. Penerbit Universiti Kebangsaan Malaysia 2020-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15912/1/14.pdf Elfahmi, and Adnyana, I Ketut and Fitria, Ika and Taufikurahman, Taufik (2020) Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans. Sains Malaysiana, 49 (9). pp. 2159-2168. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil9_2020/KandunganJilid49Bil9_2020.html |
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The diabetes mellitus is one of the chronic diseases that has high prevalence rates in the world. It is defined as a state of hyperglycemia which usually accompanied by increasing blood glucose level. The combination of Phyllanthus niruri herbs and Zingiber americans rhizome has been produced as herbal medicine for the treatment of diabetes. The efficacy of combination of these plants is still based on empirical data. This research aimed to prove the antidiabetes activity of herbal medicine product containing P. niruri and Z. americans in vivo. Antidiabetes activity was tested using oral glucose tolerance and alloxan induced methods. The blood glucose levels were measured in each experiment. In addition, the plasma triglyceride and total cholesterol levels were also measured. The results showed that the decrease of blood glucose levels on oral glucose tolerance method were 40.98, 44.84, and 47.02% at doses of 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. While the decrease in blood glucose levels in alloxan induced method were 33.05, 38.82, and 41.79% at dose 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. The extract of dose 203 mg/kg BW appeared to be the most potent to decrease blood glucose levels in both methods, but did not show suppression activity of triglycerides and total cholesterol plasma. Suppression activities of serum triglycerides and total cholesterol were shown after treatment with the extract dose 90 and 135 mg/kg BW, which were significantly different to control (p < 0.05). The herbal product contains flavonoid, phenol and tannin, which total of each were 0.15, 0.16, and 1.85% w/w, respectively. |
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Elfahmi, Adnyana, I Ketut Fitria, Ika Taufikurahman, Taufik |
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Elfahmi, Adnyana, I Ketut Fitria, Ika Taufikurahman, Taufik Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans |
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Elfahmi, Adnyana, I Ketut Fitria, Ika Taufikurahman, Taufik |
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Elfahmi, |
title |
Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans |
title_short |
Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans |
title_full |
Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans |
title_fullStr |
Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans |
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Antidiabetes activity of herbal product containing Phyllanthus niruri and Zingiber americans |
title_sort |
antidiabetes activity of herbal product containing phyllanthus niruri and zingiber americans |
publisher |
Penerbit Universiti Kebangsaan Malaysia |
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2020 |
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http://journalarticle.ukm.my/15912/1/14.pdf http://journalarticle.ukm.my/15912/ http://www.ukm.my/jsm/malay_journals/jilid49bil9_2020/KandunganJilid49Bil9_2020.html |
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