STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
Solitary fibrous tumour (SFT) is a fibrotic neoplasm, also previously designated as hemangiopericytoma. STAT6 is a protein for signal tranducers and activators of transcription (STAT) family which is involved in immune function and early cell growth. Oncogenic alteration of STAT6 plays an importa...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/15546/1/4_ms0265_pdf_97376.pdf http://journalarticle.ukm.my/15546/ https://www.medicineandhealthukm.com/toc/14/2 |
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| Summary: | Solitary fibrous tumour (SFT) is a fibrotic neoplasm, also previously designated as
hemangiopericytoma. STAT6 is a protein for signal tranducers and activators of
transcription (STAT) family which is involved in immune function and early cell
growth. Oncogenic alteration of STAT6 plays an important role for specific driver for tumour genesis of solitary fibrous tumour via NAB2-STAT6 fusion gene. The aim
of the study was to compare and evaluate STAT6 expression between SFT and other
soft tissue histological mimics. We evaluated a total of 30 cases material formalin
fixed paraffin embedded tissue block previously diagnosed SFT cases (n=14) and
soft tissue tumours mimic cases (n=16) over period of 15 years. Fourteen SFT cases
(100%) showed nuclear expression of STAT6, which was diffuse and intense. All
other tumour types were negative for STAT6, except for one case of dedifferentiated
liposarcoma, one gastrointestinal stromal tumour and one spindle cell lipoma,
which showed weak non-specific cytoplasmic staining. Nuclear STAT6 expression
is useful and reliable as adjunctive marker for solitary fibrous tumour when the
diagnosis is inconclusive by conventional methods. |
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