Detection of haemoglobin S using multiplex ligation-dependent probe amplification and flow-through hybridization techniques: experience in a tertiary hospital

• Main Authors: Wee, SY, Hafiza Alauddin,, Raja Zahratul Azma Raja Sabudin,, Norunaluwar Jalil,, Azlin Ithnin,, Malisa MY,, Qistina WN,, Ainoon O,
• Format: Article
• Language: English
• Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2020
• Online Access: http://journalarticle.ukm.my/15113/1/10_ms0352_pdf_16952.pdf; http://journalarticle.ukm.my/15113/; http://www.medicineandhealthukm.com/toc/15/1

Haemoglobin S (HbS, α2β26GluVal) is a variant haemoglobin resulted from GAGGTG mutation on codon 6 of HBB gene. HbS haemoglobinopathy is uncommon in Malaysia and mainly seen in immigrants. However, Malaysian Indians and Malays are rarely affected. This study reviewed the laboratory findings of pat...