DNA methylation of human choline kinase alpha gene

• Main Authors: Siti Aisyah Faten Mohamed Sa'dom,, Nur Farah Hani Azemi,, Mohammad Shahrizal Mohammad Umar,, Yoke, Hiang Yee, Wei, Cun See Too, Ling, Ling Few
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2020
• Online Access: http://journalarticle.ukm.my/14747/1/ARTIKEL%2020.pdf; http://journalarticle.ukm.my/14747/; http://www.ukm.my/jsm/malay_journals/jilid49bil1_2020/KandunganJilid49Bil1_2020.html

Increased level of choline kinase (CK) is a common feature in cancers and inhibition of this enzyme has been applied as anticancer strategy. DNA methylation of gene promoter especially at CpG island is associated with suppression of gene expression. Despite the importance of CK especially the alpha...