Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer

The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or perineural (PNI) invasion could significantly influence on the survival rates, treatment optio...

Full description

Saved in:
Bibliographic Details
Main Authors: Nadiah Abu,, Nurul-Syakima Ab Mutalib,, Rahman Jamal,
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/13246/1/35-137-1-PB.pdf
http://journalarticle.ukm.my/13246/
http://spaj.ukm.my/apjmm/index.php/apjmm/issue/view/19
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-ukm.journal.13246
record_format eprints
spelling my-ukm.journal.132462019-08-02T04:20:10Z http://journalarticle.ukm.my/13246/ Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal, The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or perineural (PNI) invasion could significantly influence on the survival rates, treatment options and recurrence tendencies. To date, no study has analyzed the molecular profile of the concomitant existence of LVI and PNI in CRC. Here, we reanalyzed The Cancer Genome Atlas (TCGA) CRC datasets and focused on cases where the information regarding LVI and PNI are available (n=176). We performed differential gene expression, methylation and microRNA analysis by comparing the groups having both or either LVI and PNI with the control group (LVI negative and PNI negative). Although there was no significant difference in the methylation and miRNA profiles, we identified a number of differentially expressed genes (DEGs). The comparison between the LVI+PNI+ and LVI-PNI- groups revealed key DEGs including SFTA2, PHACTR3, CRABP2, ODZ3, GRP, HAP1, CSDC2, TMEM59L and HDAC9. Meanwhile, in the LVI-PNI+ vs LVI-PNI- group, some of the DEGs found were PTPRR, EFNA2, FGF20, IGFL4, METRN and IGFBPL1. We believe that this study could be beneficial and add value to further understand the complex molecular profiles of CRC. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13246/1/35-137-1-PB.pdf Nadiah Abu, and Nurul-Syakima Ab Mutalib, and Rahman Jamal, (2018) Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer. Asia-Pacific Journal of Molecular Medicine, 8 (2). pp. 1-13. ISSN 2232-0326 http://spaj.ukm.my/apjmm/index.php/apjmm/issue/view/19
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or perineural (PNI) invasion could significantly influence on the survival rates, treatment options and recurrence tendencies. To date, no study has analyzed the molecular profile of the concomitant existence of LVI and PNI in CRC. Here, we reanalyzed The Cancer Genome Atlas (TCGA) CRC datasets and focused on cases where the information regarding LVI and PNI are available (n=176). We performed differential gene expression, methylation and microRNA analysis by comparing the groups having both or either LVI and PNI with the control group (LVI negative and PNI negative). Although there was no significant difference in the methylation and miRNA profiles, we identified a number of differentially expressed genes (DEGs). The comparison between the LVI+PNI+ and LVI-PNI- groups revealed key DEGs including SFTA2, PHACTR3, CRABP2, ODZ3, GRP, HAP1, CSDC2, TMEM59L and HDAC9. Meanwhile, in the LVI-PNI+ vs LVI-PNI- group, some of the DEGs found were PTPRR, EFNA2, FGF20, IGFL4, METRN and IGFBPL1. We believe that this study could be beneficial and add value to further understand the complex molecular profiles of CRC.
format Article
author Nadiah Abu,
Nurul-Syakima Ab Mutalib,
Rahman Jamal,
spellingShingle Nadiah Abu,
Nurul-Syakima Ab Mutalib,
Rahman Jamal,
Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
author_facet Nadiah Abu,
Nurul-Syakima Ab Mutalib,
Rahman Jamal,
author_sort Nadiah Abu,
title Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_short Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_full Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_fullStr Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_full_unstemmed Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
title_sort gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/13246/1/35-137-1-PB.pdf
http://journalarticle.ukm.my/13246/
http://spaj.ukm.my/apjmm/index.php/apjmm/issue/view/19
_version_ 1643739021112770560
score 13.214268