Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II mediated BMP4 oxidative stress cascade

BACKGROUND AND PURPOSE: Boldine is a potent natural antioxidant present in the leaves and bark of the Chilean boldo tree. Here we assessed the protective effects of boldine on endothelium in a range of models of diabetes, ex vivo and in vitro. EXPERIMENTAL APPROACH: Vascular reactivity was studied i...

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Bibliographic Details

Main Authors:	Lau, Y.S., Tian, X.Y., Mustafa, Mohd Rais, Murugan, D., Liu, J., Zhang, Y., Lau, C.W., Huang, Y.
Format:	Article
Published:	Nature Publishing Group 2013
Subjects:	R Medicine RM Therapeutics. Pharmacology
Online Access:	http://eprints.um.edu.my/9801/ http://onlinelibrary.wiley.com/doi/10.1111/bph.12350/full
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