Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells

Background We previously showed that pancreatic stellate cells (PSC) secreted interleukin (IL)-6 and promoted pancreatic ductal adenocarcinoma (PDAC) cell proliferation via nuclear factor erythroid 2 (Nrf2)-mediated metabolic reprogramming. Epithelial-mesenchymal transition (EMT) is a key process fo...

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Bibliographic Details

Main Authors:	Wu, Yuan Seng, Chung, Ivy, Wong, Won Fen, Masamune, Atsushi, Sim, Maw Shin, Looi, Chung Yeng
Format:	Article
Published:	Elsevier 2017
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/22775/ https://doi.org/10.1016/j.bbagen.2016.10.006
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