Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-kB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach

Ethnopharmacological relevance: Clausena excavata Burm. f. has been used in folk medicines in eastern Thailand for the treatment of cancer. Materials and methods: To investigate the apoptosis mechanism, we isolated dentatin (DTN) from this plant using a bioassay-guided approach. DTN-induced cytotoxi...

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Main Authors:	Arbab, I.A., Abdul, A.B., Sukari, M.A., Abdullah, R., Syam, S., Kamalidehghan, B., Ibrahim, M.Y., Taha, M.M.E., Abdelwahab, S.I., Ali, H.M., Mohan, S.
Format:	Article
Language:	en
Published:	Elsevier 2013
Subjects:	QD Chemistry
Online Access:	http://eprints.um.edu.my/10575/1/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF-7_cells.pdf http://eprints.um.edu.my/10575/
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