Identification of Protein Kinase Inhibitory Activities Fromstreptomyces Strain H7372 for Potential Use As Anti-Canceragent

• 主要作者: Hassan, Masriana
• 格式: Thesis
• 语言: English
• 出版: 2007
• 在线阅读: http://psasir.upm.edu.my/id/eprint/6438/1/FPSK%28M%29_2007_18.pdf; http://psasir.upm.edu.my/id/eprint/6438/

Aberrations in the phospbatidylinositol3-kinase (PI3K)IAkt pathway have been found in a wide spectrum of human cancers. Activation of Akt and inactivation of the downstream substrates such as GSK-3P, BAD and Forkhead family (FKHR) proteins are relevant to promote cell survival, proliferation and...