Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

• 主要な著者: Razavi, M., Karimian, H., Yeong, C.H., Fadaeinasab, M., Khaing, S.L., Chung, L.Y., Mohamad Haron, D.E., Noordin, M.I.
• フォーマット: 論文
• 言語: English
• 出版事項: Dove Medical Press 2016
• 主題: R Medicine
• オンライン･アクセス: http://eprints.um.edu.my/19043/1/Gastroretentive_behavior_of_orally_administered_radiolabeled_tamarind_seed_formulations_in_rabbits_validated_by_gamma_scintigraphy.pdf; http://eprints.um.edu.my/19043/; http://dx.doi.org/10.2147/DDDT.S115466

This study aimed to formulate floating gastroretentive tablets containing metformin hydrochloric acid (HCl), using various grades of hydrogel such as tamarind powders and xanthan to overcome short gastric residence time of the conventional dosage forms. Different concentrations of the hydrogels were...