The impact of direct nucleation control on crystal size distribution in pharmaceutical crystallization processes

• 主要な著者: Abu Bakar, Mohd Rushdi, Nagy, Zoltan K., Saleemi, Ali N., Rielly, Chris D.
• フォーマット: 論文
• 言語: English
• 出版事項: American Chemical Society 2009
• 主題: QD Chemistry; TP Chemical technology
• オンライン･アクセス: http://irep.iium.edu.my/335/1/cgd_2009_rushdi.pdf; http://irep.iium.edu.my/335/; http://pubs.acs.org/doi/abs/10.1021/cg800595v

The control of crystal size distribution (CSD) in pharmaceutical crystallization is of primary importance, as downstream processes such as filtration or drying are greatly affected by the properties of the CSD. It is recognized that the variability in the final CSD is mainly caused by the significan...