Inhibition of junctional protein disruption by 2,4,6-trihydroxy-3- geranyl acetophenone in lipopolysaccharide-induced endothelial hyperpermeability via GEF-H1/RhoA/ROCK pathway

2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) is a bioactive phloroglucinol compound found in the leaves of Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley. Our previous study has proven that tHGA exhibited significant in vitro barrier protective effects against lipopolysaccharide (LPS) inducti...

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Main Authors:	Yee, Han Chan, Kong, Yen Liew, Kamal Rullah, Hanis Hazeera Harith, Ji, Wei Tan, Daud Ahmad Israf, Khozirah Shaari, Mexmollen Marcus, Chau Ling Tham
Format:	Article
Language:	en
Published:	Springer Nature 2025
Subjects:	QP501-801 Animal biochemistry
Online Access:	https://eprints.ums.edu.my/id/eprint/45585/1/FULLTEXT.pdf https://eprints.ums.edu.my/id/eprint/45585/ https://doi.org/10.1007/s00210-025-04627-5
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