Design and Synthesis of New Barbituric- and Thiobarbituric Acid Derivatives as Potent Urease Inhibitors: Structure Activity Relationship and Molecular Modeling Studies

In this study 36 new compounds were synthesized by condensing barbituric acid or thiobarbituric acid and respective anilines (bearing different substituents) in the presence of triethyl orthoformate in good yields. In vitro urease inhibition studies against jack bean urease revealed that barbituric...

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Main Authors:	Rauf, Abdul, Shahzad, Sohail Anjum, Bajda, Marek, Yar, Muhammad, Ahmed, Faiz, Hussain, Nazar, Akhtar, Muhammad Nadeem, Khan, Ajmal, Jończyk, Jakub
Format:	Article
Language:	en
Published:	Elsevier Ltd 2015
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/9307/1/Design%20and%20Synthesis%20of%20New%20Barbituric-%20and%20Thiobarbituric%20Acid%20Derivatives%20as%20Potent%20Urease%20Inhibitors-%20Structure%20Activity%20Relationship%20And%20Molecular%20Modeling%20Studies.pdf http://umpir.ump.edu.my/id/eprint/9307/ http://dx.doi.org/10.1016/j.bmc.2015.05.038
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