Wound healing potentials of terpenoids from Malaysian stingless bee propolis: integrated network pharmacology and molecular docking approaches
Wounds offer major health concerns and cause a great deal of economic, financial, and social hardship for hospitals, patients, families, and caretakers worldwide. Wounds are said to result from natural, chemical, or thermal stressors that weaken the skin's structure. Therefore, developing novel...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Biointerface Research
2025
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| Subjects: | |
| Online Access: | https://umpir.ump.edu.my/id/eprint/46292/1/BRIAC156.088.pdf https://umpir.ump.edu.my/id/eprint/46292/ https://biointerfaceresearch.com/wp-content/uploads/2025/11/BRIAC156.088.pdf |
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| Summary: | Wounds offer major health concerns and cause a great deal of economic, financial, and social hardship for hospitals, patients, families, and caretakers worldwide. Wounds are said to result from natural, chemical, or thermal stressors that weaken the skin's structure. Therefore, developing novel medications for wound healing is crucial to address the gaps in managing various types of wounds effectively. This study employed molecular docking and network pharmacology to investigate the effects of these compounds on biological systems and assess the efficacy of stingless bee propolis terpenoids in wound care. Using STRING, Cytoscape 3.10.2, and DAVID software, a network pharmacology analysis was conducted, and a network of interaction targets related to wound healing was produced. GO, KEGG, and Reactome analyses were employed to identify the specific biological processes, cellular compartments, and molecular functions associated with wounds. Additionally, brief and preliminary molecular docking research was conducted to examine the interactions between the terpenoids of propolis from stingless bees and the target protein, which was selected based on its rank value. Based on network pharmacology analysis, 48 hub genes were identified as potential therapeutic targets and are implicated in the R-HSA-162582 Signal Transduction signaling pathway related to wound healing. Furthermore, α-Eudesmol showed the highest binding score for ESR1 (-8.1 kcal/mol), according to docking studies. This study suggests that α-Eudesmol may improve wound healing. These findings offer the chance to demonstrate the effectiveness of α-Eudesmol as a multi-target medication in wound patients through both in vitro and in vivo investigations. |
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