Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode

We have identified a novel 7-azaindole series of anaplastic lymphoma kinase (ALK) inhibitors. Compounds 7h, 7m and 7n demonstrate excellent potencies in biochemical and cellular assays. X-ray crystal structure of one of the compounds (7k) revealed a unique binding mode with the benzyl group occupyin...

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Main Authors:	Gummadi, V.R., Rajagopalan, S., Looi, C.Y., Paydar, M., Renukappa, G.A., Ainan, B.R., Krishnamurthy, N.R., Panigrahi, S.K., Mahasweta, K., Raghuramachandran, S., Rajappa, M., Ramanathan, A., Lakshminarasimhan, A., Ramachandra, M., Wong, Pooi Fong, Mustafa, Mohd Rais, Nanduri, S., Hosahalli, S.
Format:	Article
Language:	en
Published:	2013
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/8532/1/Gummadi-2013-Discovery_of_7-azain.pdf http://eprints.um.edu.my/8532/ http://www.sciencedirect.com/science/article/pii/S0960894X13008044
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