Towards a selective cytotoxic agent for prostate cancer: interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase I

Four thiosemicarbazones ligands,H3T(1),H3M(2),H3E(3) andH3P(4) have been prepared with good yield by refluxing 2,4-dihydroxybenzaldehyde with N(4)-substituted thiosemicarbazide in ethanol (H3T(1) = 2,4-dihydroxybenzaldehyde thiosemicarbazone;H3M(2) = 2,4-dihydroxybenzaldehyde 4-methylthiosemicarbazo...

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Main Authors:	Tan, K.W., Seng, H.L., Lim, F.S., Cheah, S.C., Ng, C.H., Koo, K.S., Mustafa, Mohd Rais, Ng, S.W., Maah, M.J.
Format:	Article
Language:	en
Published:	2012
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/3295/1/Towards_a_selective_cytotoxic_agent_for_prostate_cancer_Interaction_of_zinc.pdf http://eprints.um.edu.my/3295/ http://www.sciencedirect.com/science/article/pii/S0277538712001404
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