M630L mutation disrupts the structure conformation of Bruton tyrosine kinase (BTK) domain in patient with x-linked agammaglobulinemia: insights from in silico

X-Linked Agammaglobulinemia (XLA) is a rare inherited disease, attributed to mutations found in the Bruton Tyrosine Kinase (BTK) gene. This research outlines the application of Molecular Modelling and Simulation to predict the effects of a novel non-synonymous Single Nucleotide Polymorphism (nsSNP)...

Full description

Bibliographic Details

Main Authors:	Mohd Ruzani, Muhammad Syahrul Nizam, Mohd Tahab, Siti Fatimah, Mat Ripen, Adiratna, Mohamad, Saharuddin, Abdul Hamid, Azzmer Azzar, Ismail, Che Muhammad Khairul Hisyam, Merican, Amir Feisal
Format:	Article
Language:	en en
Published:	UTM Press 2025
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/118807/6/118807_M630L%20mutation%20disrupts%20the%20structure%20conformation%20of%20Bruton%20tyrosine%20kinase.pdf http://irep.iium.edu.my/118807/7/118807_M630L%20mutation%20disrupts%20the%20structure%20conformation%20of%20Bruton%20tyrosine%20kinase_Scopus.pdf http://irep.iium.edu.my/118807/ https://journals.utm.my/jurnalteknologi/article/view/22318
Tags:	Add Tag No Tags, Be the first to tag this record!