Streptococcus gallolyticus infection: a neglected marker for colorectal cancer?
Colorectal cancer (CRC) is the second leading cancer in Malaysia with mostly detected at later stage, III and IV due to lack of awareness of CRC symptoms and signs. CRC is a multifactorial, however the clinical association of Streptococcus gallolyticus (S. gallolyticus) infection with the developm...
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| Format: | Proceeding Paper |
| Language: | en |
| Published: |
2022
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| Online Access: | http://irep.iium.edu.my/100025/1/Streptococcus%20gallolyticus%20infection.pdf http://irep.iium.edu.my/100025/ |
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| author | Ismail, Che Muhammad Khairul Hisyam Aidid, Edre Mohammad Hamzah, Hairul Aini Shalihin, Mohd Shaiful Ehsan Md Nor, Azmi |
| author_facet | Ismail, Che Muhammad Khairul Hisyam Aidid, Edre Mohammad Hamzah, Hairul Aini Shalihin, Mohd Shaiful Ehsan Md Nor, Azmi |
| author_sort | Ismail, Che Muhammad Khairul Hisyam |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Colorectal cancer (CRC) is the second leading cancer in Malaysia with mostly detected at later stage,
III and IV due to lack of awareness of CRC symptoms and signs. CRC is a multifactorial, however the
clinical association of Streptococcus gallolyticus (S. gallolyticus) infection with the development of
colorectal cancer were reported. Thus, a case-control study was conducted to identify the correlation
and predictors of S. gallolyticus infection towards CRC among patients attending Sultan Ahmad Shah
Medical Centre@IIUM. A total of 33 stool sample from patient diagnosed with CRC and 80 stool
sample from patient without CRC attending Sultan Ahmad Shah Medical Centre@IIUM were
collected and proceeded with iFOBT test and PCR assay for detection of S. gallolyticus.. In this study,
the proportion of S. gallolyticus infection was higher among CRC patients (48.5%) as compared to the
control group (20%). The Pearson’s, χ2
or Fisher’s exact analysis shows that the presence of occult
blood in stool, S. gallolyticus infection, and family history were significantly associated with the
development of CRC (p-value < 0.05). The best multivariate logistic regression model showed that
positive stool PCR for S. gallolyticus had the lowest relative standard error (RSE) and almost 5 times
the odds to develop CRC after controlling other factors (adjusted odds ratio= 4.7, 95% confidence
interval= 1.7 – 12.6, RSE = 59.6%). This finding suggested that the S. gallolyticus infection was the
strongest predictor towards development of CRC and potentially be used as a predictive marker for
early detection of disease progression. |
| format | Proceeding Paper |
| id | my.iium.irep-100025 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en |
| publishDate | 2022 |
| record_format | dspace |
| spelling | my.iium.irep-1000252023-12-05T04:13:06Z http://irep.iium.edu.my/100025/ Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? Ismail, Che Muhammad Khairul Hisyam Aidid, Edre Mohammad Hamzah, Hairul Aini Shalihin, Mohd Shaiful Ehsan Md Nor, Azmi QR Microbiology R Medicine (General) RA Public aspects of medicine RC270 Neoplasms. Tumors. Oncology-Cancer and Other Malignant Neoplasms-Therapeutics Colorectal cancer (CRC) is the second leading cancer in Malaysia with mostly detected at later stage, III and IV due to lack of awareness of CRC symptoms and signs. CRC is a multifactorial, however the clinical association of Streptococcus gallolyticus (S. gallolyticus) infection with the development of colorectal cancer were reported. Thus, a case-control study was conducted to identify the correlation and predictors of S. gallolyticus infection towards CRC among patients attending Sultan Ahmad Shah Medical Centre@IIUM. A total of 33 stool sample from patient diagnosed with CRC and 80 stool sample from patient without CRC attending Sultan Ahmad Shah Medical Centre@IIUM were collected and proceeded with iFOBT test and PCR assay for detection of S. gallolyticus.. In this study, the proportion of S. gallolyticus infection was higher among CRC patients (48.5%) as compared to the control group (20%). The Pearson’s, χ2 or Fisher’s exact analysis shows that the presence of occult blood in stool, S. gallolyticus infection, and family history were significantly associated with the development of CRC (p-value < 0.05). The best multivariate logistic regression model showed that positive stool PCR for S. gallolyticus had the lowest relative standard error (RSE) and almost 5 times the odds to develop CRC after controlling other factors (adjusted odds ratio= 4.7, 95% confidence interval= 1.7 – 12.6, RSE = 59.6%). This finding suggested that the S. gallolyticus infection was the strongest predictor towards development of CRC and potentially be used as a predictive marker for early detection of disease progression. 2022-08-10 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/100025/1/Streptococcus%20gallolyticus%20infection.pdf Ismail, Che Muhammad Khairul Hisyam and Aidid, Edre Mohammad and Hamzah, Hairul Aini and Shalihin, Mohd Shaiful Ehsan and Md Nor, Azmi (2022) Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? In: Malaysian Society for Microbiology Postgraduate Symposium (MSMPS2022), 10-11 August 2022, Online. (Unpublished) |
| spellingShingle | QR Microbiology R Medicine (General) RA Public aspects of medicine RC270 Neoplasms. Tumors. Oncology-Cancer and Other Malignant Neoplasms-Therapeutics Ismail, Che Muhammad Khairul Hisyam Aidid, Edre Mohammad Hamzah, Hairul Aini Shalihin, Mohd Shaiful Ehsan Md Nor, Azmi Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| title | Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| title_full | Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| title_fullStr | Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| title_full_unstemmed | Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| title_short | Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| title_sort | streptococcus gallolyticus infection: a neglected marker for colorectal cancer? |
| topic | QR Microbiology R Medicine (General) RA Public aspects of medicine RC270 Neoplasms. Tumors. Oncology-Cancer and Other Malignant Neoplasms-Therapeutics |
| url | http://irep.iium.edu.my/100025/1/Streptococcus%20gallolyticus%20infection.pdf http://irep.iium.edu.my/100025/ |
| url_provider | http://irep.iium.edu.my/ |