Streptococcus gallolyticus infection: a neglected marker for colorectal cancer?
Colorectal cancer (CRC) is the second leading cancer in Malaysia with mostly detected at later stage, III and IV due to lack of awareness of CRC symptoms and signs. CRC is a multifactorial, however the clinical association of Streptococcus gallolyticus (S. gallolyticus) infection with the developm...
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| Main Authors: | , , , , |
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| Format: | Proceeding Paper |
| Language: | en |
| Published: |
2022
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/100025/1/Streptococcus%20gallolyticus%20infection.pdf http://irep.iium.edu.my/100025/ |
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| Summary: | Colorectal cancer (CRC) is the second leading cancer in Malaysia with mostly detected at later stage,
III and IV due to lack of awareness of CRC symptoms and signs. CRC is a multifactorial, however the
clinical association of Streptococcus gallolyticus (S. gallolyticus) infection with the development of
colorectal cancer were reported. Thus, a case-control study was conducted to identify the correlation
and predictors of S. gallolyticus infection towards CRC among patients attending Sultan Ahmad Shah
Medical Centre@IIUM. A total of 33 stool sample from patient diagnosed with CRC and 80 stool
sample from patient without CRC attending Sultan Ahmad Shah Medical Centre@IIUM were
collected and proceeded with iFOBT test and PCR assay for detection of S. gallolyticus.. In this study,
the proportion of S. gallolyticus infection was higher among CRC patients (48.5%) as compared to the
control group (20%). The Pearson’s, χ2
or Fisher’s exact analysis shows that the presence of occult
blood in stool, S. gallolyticus infection, and family history were significantly associated with the
development of CRC (p-value < 0.05). The best multivariate logistic regression model showed that
positive stool PCR for S. gallolyticus had the lowest relative standard error (RSE) and almost 5 times
the odds to develop CRC after controlling other factors (adjusted odds ratio= 4.7, 95% confidence
interval= 1.7 – 12.6, RSE = 59.6%). This finding suggested that the S. gallolyticus infection was the
strongest predictor towards development of CRC and potentially be used as a predictive marker for
early detection of disease progression. |
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