Synthesis, molecular docking and dynamic studies of 3-cyano-6-hydroxy-5-pentaloxy N-Boc Cyclohexene as key intermediate for oseltamivir phosphate

A key intermediate for oseltamivir phosphate synthesis, compound 15 (3-cyano-6-hydroxy-5-pentaloxy-N-Boccyclohexene), was synthesized from inexpensive, commercially available 1,4-cyclohexadiene (4). The synthesis involved eight steps, sequentially introducing substituents onto a cyclohexene ring: An...

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Main Authors:	Zurhana Mat Hussin, Najmah P.S Hasan, Fazni Susila Abd Ghani, Shaari Daud, Mohd Salleh Rofiee, Syahrul Imran, Mohd Tajudin Mohd Ali
Format:	Article
Language:	en
Published:	Penerbit Universiti Kebangsaan Malaysia 2025
Online Access:	http://journalarticle.ukm.my/26323/1/SMS%207.pdf http://journalarticle.ukm.my/26323/ https://www.ukm.my/jsm/english_journals/vol54num9_2025/contentsVol54num9_2025.html
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