Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants

• Main Authors: Fook-Choe, Cheah,, Fei-Liang, Wong,, Azlin, Ithnin,, Alexander V., Peskin,, Christine C, Winterbourn,, Ainoon, Othman,
• Format: Article
• Language: English
• Published: Federation Amer Soc Exp Biol 2015
• Subjects: Hemolytic Anemia; Antioxidant Defense; Hydrogen Peroxide
• Online Access: http://ddms.usim.edu.my/handle/123456789/8290; http://www.fasebj.org/content/28/7/3205.full.pdf+html?sid=fe49b0d9-ac36-404e-b08c-592bc0526eb5

Erythrocytes require glucose-6-phosphate dehydrogenase (G6PD) to generate NADPH and protect themselves against hemolytic anemia induced by oxidative stress. Peroxiredoxin 2 (Prx2) is a major antioxidant enzyme that requires NADPH to recycle its oxidized (disulfide-bonded) form. Our aims were to dete...