Three new amides from Streptomyces sp. H7372
Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Química
2011
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Online Access: | http://psasir.upm.edu.my/id/eprint/24724/1/Three%20new%20amides%20from%20streptomyces%20sp.pdf http://psasir.upm.edu.my/id/eprint/24724/ |
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Summary: | Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(δAla-L- Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two- hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His - and inactive on SD His + at 2.5 μg per disk, respectively. |
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