Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.

• Main Authors: Rasol, Nurulfazlina Edayah, Ahmad, Fasihuddin Badruddin, Lim, Xiangyin, Chung, Felicia Fei Lei, Leong, Cheeonn, Mai, Chun Wai, Bihud, Nur Vicky, Zaki, Hamizah Mohd, Ismail, Nor Hadiani
• Format: Article
• Language: English
• Published: Elsevier Ltd 2018
• Subjects: S Agriculture (General)
• Online Access: http://ir.unimas.my/id/eprint/19852/3/Cytotoxic.pdf; http://ir.unimas.my/id/eprint/19852/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041685981&doi=10.1016%2fj.phytol.2018.01.009&partnerID=40&md5=907cd8c69b36574e5c2213af95f78daa

Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic techniques and the absolute configuration of 1 was established by single-crystal X-ray diffraction. Alkaloid 1 showed cytotoxic activity on human colon and lung cancer cell lines with IC50 values ranging from 5.32 to 9.91 μM. © 2018 Phytochemical Society of Europe