Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.
Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatu...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2018
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/19852/3/Cytotoxic.pdf http://ir.unimas.my/id/eprint/19852/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041685981&doi=10.1016%2fj.phytol.2018.01.009&partnerID=40&md5=907cd8c69b36574e5c2213af95f78daa |
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| Summary: | Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic techniques and the absolute configuration of 1 was established by single-crystal X-ray diffraction. Alkaloid 1 showed cytotoxic activity on human colon and lung cancer cell lines with IC50 values ranging from 5.32 to 9.91 μM. © 2018 Phytochemical Society of Europe |
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