Natural human infections with plasmodium cynomolgi and other malaria species in an elimination setting in Sabah, Malaysia

To determine the presence and species composition of malaria infections, we screened a subset of samples collected during a cross-sectional survey in Northern Sabah, Malaysia using highly sensitive molecular techniques. Results identified 54 asymptomatic submicroscopic malaria infections, including...

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Bibliographic Details
Main Authors: Lynn Grignard, Sonal Shah, Chua, Tock Hing, Timothy William, Chris J. Drakeley, Kimberly M. Fornace
Format: Article
Language:English
English
Published: Oxford University Press 2019
Subjects:
Online Access:https://eprints.ums.edu.my/id/eprint/33418/1/Natural%20human%20infections%20with%20plasmodium%20cynomolgi%20and%20other%20malaria%20species%20in%20an%20elimination%20setting%20in%20Sabah%2C%20Malaysia.ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/33418/2/Natural%20human%20infections%20with%20plasmodium%20cynomolgi%20and%20other%20malaria%20species%20in%20an%20elimination%20setting%20in%20Sabah%2C%20Malaysia.pdf
https://eprints.ums.edu.my/id/eprint/33418/
https://academic.oup.com/jid/article/220/12/1946/5550405
https://doi.org/10.1093/infdis/jiz397
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Summary:To determine the presence and species composition of malaria infections, we screened a subset of samples collected during a cross-sectional survey in Northern Sabah, Malaysia using highly sensitive molecular techniques. Results identified 54 asymptomatic submicroscopic malaria infections, including a large cluster of Plasmodium falciparum and 3 P. knowlesi infections. We additionally identified 2 monoinfections with the zoonotic malaria Plasmodium cynomolgi, both in individuals reporting no history of forest activities or contact with macaques. Results highlight the need for improved surveillance strategies to detect these infections and determine public health impacts.