Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo
Background: In October 2016, a mumps outbreak occurred among the students living in the on-campus dormitory of a public university located in Kota Kinabalu, Sabah, Malaysia. This study aimed to investigate the outbreak and identify the genotype of the mumps virus (MuV) strain that was involved in th...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English English |
Published: |
BioMed Central Ltd
2022
|
Subjects: | |
Online Access: | https://eprints.ums.edu.my/id/eprint/32808/1/Mumps%20outbreak%20in%20university%20students.pdf https://eprints.ums.edu.my/id/eprint/32808/2/Mumps%20outbreak%20in%20university%20students1.pdf https://eprints.ums.edu.my/id/eprint/32808/ https://tropmedhealth.biomedcentral.com/articles/10.1186/s41182-022-00411-w https://doi.org/10.1186/s41182-022-00411-w |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.ums.eprints.32808 |
---|---|
record_format |
eprints |
spelling |
my.ums.eprints.328082022-06-16T07:14:27Z https://eprints.ums.edu.my/id/eprint/32808/ Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo Fong, Siat Yee Daisuke Mori Jecelyn Leaslie John Nelbon Giloi Mohammad Saffree Jeffree Kamruddin Ahmed R5-920 Medicine (General) RF1-547 Otorhinolaryngology Background: In October 2016, a mumps outbreak occurred among the students living in the on-campus dormitory of a public university located in Kota Kinabalu, Sabah, Malaysia. This study aimed to investigate the outbreak and identify the genotype of the mumps virus (MuV) strain that was involved in the outbreak. Main body: During the outbreak, one 21-year-old and four 20-year-old males staying in the same dormitory building were reported to have developed symptoms of mumps. Of these, two students were available during the investigation for sample collection to detect MuV by reverse transcription polymerase chain reaction (RT-PCR) of the 639- bp fragment encompassing the entire small hydrophobic (SH) gene. Nucleotide sequencing of the amplicon and phylogenetic analysis using the neighbor-joining method was performed to determine the MuV genotype. Of the two buccal swab samples, one was positive for MuV. The MuV strain in this sample belonged to genotype F and it was clustered together with genotype F strains from China with 96.84–99.68% nucleotide identity. Conclusions: Genotype F has limited circulation and is endemic in mainland China. Genotype F strains occasionally reported from other countries were epidemiologically linked to China. This study is the frst to report a case of genotype F MuV in Malaysia and no epidemiological link could be established with mainland China. The results provide important information that can assist in strategic planning to improve the prevention and control of mumps infection in Malaysia. BioMed Central Ltd 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32808/1/Mumps%20outbreak%20in%20university%20students.pdf text en https://eprints.ums.edu.my/id/eprint/32808/2/Mumps%20outbreak%20in%20university%20students1.pdf Fong, Siat Yee and Daisuke Mori and Jecelyn Leaslie John and Nelbon Giloi and Mohammad Saffree Jeffree and Kamruddin Ahmed (2022) Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo. Tropical Medicine and Health, 50 (20). pp. 1-6. ISSN 1349-4147 https://tropmedhealth.biomedcentral.com/articles/10.1186/s41182-022-00411-w https://doi.org/10.1186/s41182-022-00411-w |
institution |
Universiti Malaysia Sabah |
building |
UMS Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaysia Sabah |
content_source |
UMS Institutional Repository |
url_provider |
http://eprints.ums.edu.my/ |
language |
English English |
topic |
R5-920 Medicine (General) RF1-547 Otorhinolaryngology |
spellingShingle |
R5-920 Medicine (General) RF1-547 Otorhinolaryngology Fong, Siat Yee Daisuke Mori Jecelyn Leaslie John Nelbon Giloi Mohammad Saffree Jeffree Kamruddin Ahmed Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo |
description |
Background: In October 2016, a mumps outbreak occurred among the students living in the on-campus dormitory of a public university located in Kota Kinabalu, Sabah, Malaysia. This study aimed to investigate the outbreak and identify the genotype of the mumps virus (MuV) strain that was involved in the outbreak. Main body: During the outbreak, one 21-year-old and four 20-year-old males staying in the same dormitory building were reported to have developed symptoms of mumps. Of these, two students were available during the investigation for sample collection to detect MuV by reverse transcription polymerase chain reaction (RT-PCR) of the 639- bp fragment encompassing the entire small hydrophobic (SH) gene. Nucleotide sequencing of the amplicon and phylogenetic analysis using the neighbor-joining method was performed to determine the MuV genotype. Of the two buccal swab samples, one was positive for MuV. The MuV strain in this sample belonged to genotype F and it was clustered together with genotype F strains from China with 96.84–99.68% nucleotide identity. Conclusions: Genotype F has limited circulation and is endemic in mainland China. Genotype F strains occasionally reported from other countries were epidemiologically linked to China. This study is the frst to report a case of genotype F MuV in Malaysia and no epidemiological link could be established with mainland China. The results provide important information that can assist in strategic planning to improve the prevention and control of mumps infection in Malaysia. |
format |
Article |
author |
Fong, Siat Yee Daisuke Mori Jecelyn Leaslie John Nelbon Giloi Mohammad Saffree Jeffree Kamruddin Ahmed |
author_facet |
Fong, Siat Yee Daisuke Mori Jecelyn Leaslie John Nelbon Giloi Mohammad Saffree Jeffree Kamruddin Ahmed |
author_sort |
Fong, Siat Yee |
title |
Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo |
title_short |
Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo |
title_full |
Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo |
title_fullStr |
Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo |
title_full_unstemmed |
Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo |
title_sort |
mumps outbreak in university students: first detection of mumps virus genotype f in borneo |
publisher |
BioMed Central Ltd |
publishDate |
2022 |
url |
https://eprints.ums.edu.my/id/eprint/32808/1/Mumps%20outbreak%20in%20university%20students.pdf https://eprints.ums.edu.my/id/eprint/32808/2/Mumps%20outbreak%20in%20university%20students1.pdf https://eprints.ums.edu.my/id/eprint/32808/ https://tropmedhealth.biomedcentral.com/articles/10.1186/s41182-022-00411-w https://doi.org/10.1186/s41182-022-00411-w |
_version_ |
1760231077255839744 |
score |
13.1944895 |