Discovery of novel inhibitors from medicinal plants for v-domain ig suppressor of t-cell activation

• Main Authors: Muneer, Iqra, Ahmad, Sajjad, Naz, Anam, Abbasi, Sumra Wajid, Alblihy, Adel, Aloliqi, Abdulaziz A., Aba Alkhayl, Faris F., Alrumaihi, Faris, Ahmad, Sarfraz, El Bakri, Youness, Tahir Ul Qamar, Muhammad
• Format: Article
• Published: Frontiers Media SA 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/34453/

V-domain Ig suppressor of T cell activation (VISTA) is an immune checkpoint and is a type I transmembrane protein. VISTA is linked to immunotherapy resistance, and it is a potential immune therapeutic target, especially for triple-negative breast cancer. It expresses at a high concentration in regul...