Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation
The majority of patients with Human Immunodeficiency Virus (HIV) will have cutaneous manifestation during their disease course. We report the spectrum of cutaneous manifestations and clinicopathological concordance in the diagnosis of skin diseases in patients with HIV. Methods: A retrospective revi...
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my.um.eprints.339442022-07-21T04:51:02Z http://eprints.um.edu.my/33944/ Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation Han, Winn Hui Yong, Jo Yen Yong, Shin Shen Faheem, Nik Aimee Azizah Toh, Yen Fa Chew, Man Fong Kwan, Zhenli Raja Azwa, Raja Iskandar Shah R Medicine RL Dermatology The majority of patients with Human Immunodeficiency Virus (HIV) will have cutaneous manifestation during their disease course. We report the spectrum of cutaneous manifestations and clinicopathological concordance in the diagnosis of skin diseases in patients with HIV. Methods: A retrospective review of all cutaneous manifestations of HIV-infected patients with skin biopsy-proven histopathological confirmation, treated in the University of Malaya Medical Centre, from 2016 till 2018, was performed. Clinical characteristics and histopathological correlation of these patients were reviewed. Results: A total of 38 cases were included where the median age was 40.5 (interquartile range (IQR) 15.5). The median duration of HIV diagnosis to the development of skin disease was 3 years (IQR 7.8). Majority of our patients were male (89.5%, n = 34), and the commonest mode of transmission is men who have sex with men (36.8%, n = 14). Most patients (92.1%, n = 35) had Acquired Immunodeficiency Syndrome when they presented with skin diseases, predominantly non-infectious types (51.4%, n = 19). Commonest skin diseases include eczema (n = 7) and pruritic papular eruption of HIV (n = 6). Papules and plaques were the commonest morphology for both infectious and non-infectious skin diseases. Duration of HIV diagnosis (P = 0.018) and non-compliance to Highly Active Antiretroviral Therapy (HAART) (P = 0.014) were significantly associated with the development of non-infectious skin diseases. Overall, clinicopathological concordance was 84.2% in our centre. Conclusion: A wide spectrum of cutaneous diseases can occur in HIV patients depending on the degree of immunosuppression. skin biopsy along with appropriate stains, and microbiological cultures are important in helping clinicians clinch the right diagnosis. Wiley 2021-08 Article PeerReviewed Han, Winn Hui and Yong, Jo Yen and Yong, Shin Shen and Faheem, Nik Aimee Azizah and Toh, Yen Fa and Chew, Man Fong and Kwan, Zhenli and Raja Azwa, Raja Iskandar Shah (2021) Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation. Australasian Journal of Dermatology, 62 (3). pp. 286-291. ISSN 0004-8380, DOI https://doi.org/10.1111/ajd.13580 <https://doi.org/10.1111/ajd.13580>. 10.1111/ajd.13580 |
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R Medicine RL Dermatology Han, Winn Hui Yong, Jo Yen Yong, Shin Shen Faheem, Nik Aimee Azizah Toh, Yen Fa Chew, Man Fong Kwan, Zhenli Raja Azwa, Raja Iskandar Shah Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation |
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The majority of patients with Human Immunodeficiency Virus (HIV) will have cutaneous manifestation during their disease course. We report the spectrum of cutaneous manifestations and clinicopathological concordance in the diagnosis of skin diseases in patients with HIV. Methods: A retrospective review of all cutaneous manifestations of HIV-infected patients with skin biopsy-proven histopathological confirmation, treated in the University of Malaya Medical Centre, from 2016 till 2018, was performed. Clinical characteristics and histopathological correlation of these patients were reviewed. Results: A total of 38 cases were included where the median age was 40.5 (interquartile range (IQR) 15.5). The median duration of HIV diagnosis to the development of skin disease was 3 years (IQR 7.8). Majority of our patients were male (89.5%, n = 34), and the commonest mode of transmission is men who have sex with men (36.8%, n = 14). Most patients (92.1%, n = 35) had Acquired Immunodeficiency Syndrome when they presented with skin diseases, predominantly non-infectious types (51.4%, n = 19). Commonest skin diseases include eczema (n = 7) and pruritic papular eruption of HIV (n = 6). Papules and plaques were the commonest morphology for both infectious and non-infectious skin diseases. Duration of HIV diagnosis (P = 0.018) and non-compliance to Highly Active Antiretroviral Therapy (HAART) (P = 0.014) were significantly associated with the development of non-infectious skin diseases. Overall, clinicopathological concordance was 84.2% in our centre. Conclusion: A wide spectrum of cutaneous diseases can occur in HIV patients depending on the degree of immunosuppression. skin biopsy along with appropriate stains, and microbiological cultures are important in helping clinicians clinch the right diagnosis. |
format |
Article |
author |
Han, Winn Hui Yong, Jo Yen Yong, Shin Shen Faheem, Nik Aimee Azizah Toh, Yen Fa Chew, Man Fong Kwan, Zhenli Raja Azwa, Raja Iskandar Shah |
author_facet |
Han, Winn Hui Yong, Jo Yen Yong, Shin Shen Faheem, Nik Aimee Azizah Toh, Yen Fa Chew, Man Fong Kwan, Zhenli Raja Azwa, Raja Iskandar Shah |
author_sort |
Han, Winn Hui |
title |
Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation |
title_short |
Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation |
title_full |
Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation |
title_fullStr |
Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation |
title_full_unstemmed |
Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) infection: A retrospective review of a tertiary referral centre with clinicopathological correlation |
title_sort |
cutaneous manifestations of patients with human immunodeficiency virus (hiv) infection: a retrospective review of a tertiary referral centre with clinicopathological correlation |
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Wiley |
publishDate |
2021 |
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http://eprints.um.edu.my/33944/ |
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1739828482731409408 |
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13.1944895 |