Loop dynamics behind the affinity of DARPins towards ERK2: Molecular dynamics simulations (MDs) and elastic network model (ENM)
The binding affinity and dynamics profiles of non-phosphorylated extracellular regulated kinase 2 (ERK2), in complex with DARPins (designed ankyrin repeat proteins) as a phosphorylation inhibitor, has been investigated using molecular dynamics simulations (MDs) and elastic network model (ENM). The s...
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Main Authors: | Gautam, Vertika, Chong, Wei Lim, Chin, Sek Peng, Zain, Sharifuddin Md, Abd Rahman, Noorsaadah, Vao-soongnern, Visit, Lee, Vannajan Sanghiran |
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Format: | Article |
Published: |
Elsevier
2019
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Subjects: | |
Online Access: | http://eprints.um.edu.my/20084/ https://doi.org/10.1016/j.molliq.2018.10.157 |
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