Solid state characterization of PVP wrapped indomethacin / Nurridah Abd Halim

• Main Author: Abd Halim, Nurridah
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: Drugs and their actions; Pharmacopoeias
• Online Access: https://ir.uitm.edu.my/id/eprint/110368/1/110368.PDF; https://ir.uitm.edu.my/id/eprint/110368/

Indomethacin is a drug of poor solubility. We can enhance the solubility of the drug by adding a suitable excipient to improve the solubility. In this case, the excipient used is one of polymers which is polyvinylpyrrolidone (PVP) polymer. The technique used is polymer wrapping technique. Different weight of indomethacin is used to make four samples of PVP wrapped indomethacin. The sample is identified as sample a, sample b, sample c, and sample d. Then, the solid state characteristic of PVP wrapped indomethacin is characterized by using differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The comparison of pure materials (indomethacin and PVP) is made with PVP wrapped indomethacin.