Tissue injury characterization by pre-contrast T1 mapping post myocardial infraction

• Main Authors: Mohd Shah, Azarisman Shah, Li, Andrew, Wong, Dennis T., Richardson, James D., Chua, Seng Keong, Samaraie, Luay, Sidharta, Samuel L, Glenie, Timothy, Williams, Kerry, Koschade, Ben, Teo, Karen, Worthley, Matthew, Worthley, Stephen G.
• Format: Article
• Language: English
• Published: Society for Cardiovascular Magnetic Resonance (SCMR) 2013
• Subjects: RC Internal medicine
• Online Access: http://irep.iium.edu.my/44312/1/1532-429X-15-S1-E33.pdf; http://irep.iium.edu.my/44312/; http://www.jcmr-online.com/content/15/S1/E33

Background Myocardial scar and edema can be assessed by late gadolinium enhancement (LGE) and T2W cardiac magnetic resonance (CMR) respectively, but each has important limitations. T1-mapping has emerged as an alternative method to characterize acute ischemic injury and contemporary mapping sequences make this clinically feasible. We assessed the T1 relaxation time in myocardial segments exhibiting varying degrees of ischemic injury in patients after acute MI. Methods T2W, T1-mapping (using Shortened Modified Look-Looker Inversion recovery sequence) and LGE imaging was performed 24-72 hours after MI on a 1.5T scanner. Assessment of acute segmental damage, in a 16-segment AHA model, was performed on matched short axis slices. Mean segmental T1 values were calculated for infarcted, adjacent/edema, microvascular obstruction (MVO) or remote segments as defined by LGE.